HCID 22029002, compound → HCID 68510753, compound

HRID 1256899Notes

Reaction equation

HRID 1256899 reaction equation
[CH2:1]([N:3]([CH2:32][CH3:33])[C:4](=[O:31])[CH:5]([CH2:22][C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][CH:24]=1)[C:6]([NH:8][S:9]([C:12]1[CH:21]=[CH:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:13]=1)(=[O:11])=[O:10])=[O:7])[CH3:2].[C:34]([C:36]1[CH:37]=[C:38]([N:44]2CCNCC2)[CH:39]=[CH:40][C:41]=1[C:42]#[N:43])#[N:35]>>[C:34]([C:36]1[CH:37]=[C:38]([N:44]2[CH2:2][CH2:1][N:3]([C:4](=[O:31])[CH:5]([CH2:22][C:23]3[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][CH:24]=3)[C:6]([NH:8][S:9]([C:12]3[CH:21]=[CH:20][C:19]4[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=4)[CH:13]=3)(=[O:10])=[O:11])=[O:7])[CH2:32][CH2:33]2)[CH:39]=[CH:40][C:41]=1[C:42]#[N:43])#[N:35]

Participants

3

Reactant 2

HCID 22029002HCID 22029002, compoundHCID 86645218HCID 86645218, compound

Product 1

HCID 68510753HCID 68510753, compoundYield 67.3%

Procedure

In the same manner as in Example 1 (4), a crude product was obtained using the compound (550 mg) obtained in Example 112 (4) and N-(3,4-dicyanophenyl)piperazine (282 mg). This was purified by silica gel column chromatography to give the title compound (480 mg) as a yellow powder.

Workup

  1. customThis was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-829f184d1a1f483cb6e637f8ce8a7c03
Source dataset
uspto-grants-2013_06
Patent number
US08461209B2

Reaction notes

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