Morpholine → HCID 68507895, compound

HRID 1256901Notes

Reaction equation

HRID 1256901 reaction equation
[CH2:1]([N:3]([CH2:33][CH3:34])[C:4](=[O:32])[CH:5]([CH2:22][C:23]1[CH:28]=[CH:27][C:26]([N+:29]([O-:31])=[O:30])=[CH:25][CH:24]=1)[C:6]([NH:8][S:9]([C:12]1[CH:21]=[CH:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:13]=1)(=[O:11])=[O:10])=[O:7])[CH3:2].N1CC[O:38]CC1>>[O:38]1[CH2:2][CH2:1][N:3]([C:4](=[O:32])[CH:5]([CH2:22][C:23]2[CH:24]=[CH:25][C:26]([N+:29]([O-:31])=[O:30])=[CH:27][CH:28]=2)[C:6]([NH:8][S:9]([C:12]2[CH:21]=[CH:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH:13]=2)(=[O:10])=[O:11])=[O:7])[CH2:33][CH2:34]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 68506138HCID 68506138, compound

Product 1

HCID 68507895HCID 68507895, compound

Procedure

In the same manner as in Example 1 (4), a crude product was obtained using the compound (500 mg) obtained in Example 6 (4) and morpholine (204 μL). This was purified by silica gel column chromatography to give the title compound (304 mg) as a white powder.

Workup

  1. customThis was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-2188cefe16114b26af337d89d3e1fb52
Source dataset
uspto-grants-2013_06
Patent number
US08461209B2

Reaction notes

Loading…