2-(Methylamino)ethanol → HCID 68510103, compound

HRID 1256902Notes

Reaction equation

HRID 1256902 reaction equation
[CH2:1]([N:3]([CH2:33]C)[C:4](=[O:32])[CH:5]([CH2:22][C:23]1[CH:28]=[CH:27][C:26]([N+:29]([O-:31])=[O:30])=[CH:25][CH:24]=1)[C:6]([NH:8][S:9]([C:12]1[CH:21]=[CH:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:13]=1)(=[O:11])=[O:10])=[O:7])[CH3:2].CNCC[OH:39]>>[OH:39][CH2:2][CH2:1][N:3]([CH3:33])[C:4](=[O:32])[CH:5]([CH2:22][C:23]1[CH:24]=[CH:25][C:26]([N+:29]([O-:31])=[O:30])=[CH:27][CH:28]=1)[C:6]([NH:8][S:9]([C:12]1[CH:21]=[CH:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:13]=1)(=[O:11])=[O:10])=[O:7]

Participants

3

Reactant 2

HCID 80162-(Methylamino)ethanolHCID 68506138HCID 68506138, compound

Product 1

HCID 68510103HCID 68510103, compoundYield 80.2%

Procedure

In the same manner as in Example 1 (4), a crude product was obtained using the compound (400 mg) obtained in Example 6 (4) and N-methylethanolamine (140 mg). This was purified by silica gel column chromatography to give the title compound (322 mg) as a white powder.

Workup

  1. customThis was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-cb87152ed86b4535a0291e9bdf8ae720
Source dataset
uspto-grants-2013_06
Patent number
US08461209B2

Reaction notes

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