Benzhydrylamine → HCID 68512012, compound

HRID 1256903Notes

Reaction equation

C(N(CC)[C:4](=[O:32])[CH:5]([CH2:22][C:23]1[CH:28]=[CH:27][C:26]([N+:29]([O-:31])=[O:30])=[CH:25][CH:24]=1)[C:6]([NH:8][S:9]([C:12]1[CH:21]=[CH:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:13]=1)(=[O:11])=[O:10])=[O:7])C.[CH:35]([NH2:48])([C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1)[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1>>[C:36]1([CH:35]([C:42]2[CH:43]=[CH:44][CH:45]=[CH:46][CH:47]=2)[NH:48][C:4](=[O:32])[CH:5]([CH2:22][C:23]2[CH:24]=[CH:25][C:26]([N+:29]([O-:31])=[O:30])=[CH:27][CH:28]=2)[C:6]([NH:8][S:9]([C:12]2[CH:21]=[CH:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH:13]=2)(=[O:11])=[O:10])=[O:7])[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1

Participants

Reactant 2

HCID 7036Benzhydrylamine

HCID 68506138HCID 68506138, compound

Product 1

HCID 68512012HCID 68512012, compoundYield 31.6%

Procedure

In the same manner as in Example 1 (4), a crude product was obtained using the compound (400 mg) obtained in Example 6 (4) and benzhydrylamine (171 mg). This was purified by silica gel column chromatography to give the title compound (155 mg) as a white powder.

Workup

customThis was purified by silica gel column chromatography

Sources & evidence

ORD record: ord-f0f075b163b54647b7c0e3ef3df3cabe
Source dataset: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08461209B2

Reaction notes

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