spiro[indene-1,4'-piperidin]-3(2H)-one → HCID 68511882, compound

HRID 1256905Notes

Reaction equation

HRID 1256905 reaction equation
[CH2:1]([N:3]([CH2:33][CH3:34])[C:4](=[O:32])[CH:5]([CH2:22][C:23]1[CH:28]=[CH:27][C:26]([N+:29]([O-:31])=[O:30])=[CH:25][CH:24]=1)[C:6]([NH:8][S:9]([C:12]1[CH:21]=[CH:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:13]=1)(=[O:11])=[O:10])=[O:7])[CH3:2].[O:35]=[C:36]1[C:49]2[C:44](=[CH:45][CH:46]=[CH:47][CH:48]=2)[C:38]2(CCNCC2)[CH2:37]1>>[CH:13]1[C:14]2[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:20]=[CH:21][C:12]=1[S:9]([NH:8][C:6](=[O:7])[CH:5]([CH2:22][C:23]1[CH:24]=[CH:25][C:26]([N+:29]([O-:31])=[O:30])=[CH:27][CH:28]=1)[C:4](=[O:32])[N:3]1[CH2:1][CH2:2][C:38]2([C:44]3[C:49](=[CH:48][CH:47]=[CH:46][CH:45]=3)[C:36](=[O:35])[CH2:37]2)[CH2:34][CH2:33]1)(=[O:10])=[O:11]

Participants

3

Reactant 2

HCID 18467061spiro[indene-1,4'-piperidin]-3(2H)-oneHCID 68506138HCID 68506138, compound

Product 1

HCID 68511882HCID 68511882, compoundYield 23.7%

Procedure

In the same manner as in Example 1 (4), a crude product was obtained using the compound (300 mg) obtained in Example 6 (4) and 3-oxospiro[indane-1,4′-piperidine] (141 mg). This was purified by silica gel column chromatography to give the title compound (90 mg) as a white powder.

Workup

  1. customThis was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-f8278bfe9ad4469ba78541089fef460a
Source dataset
uspto-grants-2013_06
Patent number
US08461209B2

Reaction notes

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