N-Ethylaniline → HCID 68506202, compound

HRID 1256907Notes

Reaction equation

HRID 1256907 reaction equation
[CH2:1]([N:3]([CH2:35][CH3:36])[C:4](=[O:34])[CH:5]([CH2:22][C:23]1[CH:28]=[CH:27][C:26]([O:29][C:30]([F:33])([F:32])[F:31])=[CH:25][CH:24]=1)[C:6]([NH:8][S:9]([C:12]1[CH:21]=[CH:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:13]=1)(=[O:11])=[O:10])=[O:7])[CH3:2].C(N[C:40]1[CH:45]=CC=[CH:42][CH:41]=1)C>>[CH2:35]([N:3]([C:1]1[CH:42]=[CH:41][CH:40]=[CH:45][CH:2]=1)[C:4](=[O:34])[CH:5]([CH2:22][C:23]1[CH:24]=[CH:25][C:26]([O:29][C:30]([F:31])([F:32])[F:33])=[CH:27][CH:28]=1)[C:6]([NH:8][S:9]([C:12]1[CH:21]=[CH:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:13]=1)(=[O:10])=[O:11])=[O:7])[CH3:36]

Participants

3

Reactant 2

HCID 7670N-EthylanilineHCID 86645220HCID 86645220, compound

Product 1

HCID 68506202HCID 68506202, compoundYield 40.3%

Procedure

In the same manner as in Example 1 (4), a crude product was obtained using the compound (1.18 g) obtained in Example 117 (4) and N-ethylaniline (305 mg). This was purified by silica gel column chromatography to give the title compound (519 mg) as a white powder.

Workup

  1. customThis was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-6b7c22b1cb6d432c8ce4384f4827970b
Source dataset
uspto-grants-2013_06
Patent number
US08461209B2

Reaction notes

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