HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl isobutylmalonate → 4-methyl-2-{[((E)-styrylsulfonyl)amino]carbonyl}valeric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl isobutylmalonate | HCID 25047 | — |
| Reactant | (1E)-2-Phenylethenesulfonamide | HCID 5357731 | — |
| Product | 4-methyl-2-{[((E)-styrylsulfonyl)amino]carbonyl}valeric acid | HCID 68510454 | 96.6% |
Reaction Steps
In the same manner as in Example 1 (1), the object compound was obtained using diethyl isobutylmalonate (10.0 g). This and trans-β-styrenesulfonamide (2.91 g) were condensed in the same manner as in Example 152 (3). The condensed product was subjected to hydrolysis in the same manner as in Example 1 (3) to give the title compound (4.99 g) as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08461209B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-484ca47add534346a490a87564d41826 |
| Source note | uspto-grants-2013_06 |