N-Ethylaniline → HCID 68510657, compound

HRID 1256916Notes

Reaction equation

[C:1]([CH2:3][CH2:4][CH:5]([C:13]([NH:15][S:16](/[CH:19]=[CH:20]/[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)(=[O:18])=[O:17])=[O:14])[C:6]([N:8]([CH2:11][CH3:12])[CH2:9][CH3:10])=[O:7])#[N:2].C(N[C:30]1[CH:35]=CC=[CH:32][CH:31]=1)C>>[C:1]([CH2:3][CH2:4][CH:5]([C:13]([NH:15][S:16](/[CH:19]=[CH:20]/[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)(=[O:17])=[O:18])=[O:14])[C:6]([N:8]([CH2:9][CH3:10])[C:11]1[CH:32]=[CH:31][CH:30]=[CH:35][CH:12]=1)=[O:7])#[N:2]

Participants

Reactant 2

HCID 7670N-Ethylaniline

HCID 86645225HCID 86645225, compound

Product 1

HCID 68510657HCID 68510657, compound

Procedure

In the same manner as in Example 1 (4), a crude product was obtained using the compound (300 mg) obtained in Example 216 (2) and N-ethylaniline (123 μL). This was purified by silica gel column chromatography to give the title compound (145 mg) as a white powder.

Workup

customThis was purified by silica gel column chromatography

Sources & evidence

ORD record: ord-8c2028ba3f4b43389fa1a614fbad0a9e
Source dataset: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08461209B2

Reaction notes

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