Benzenamine, 4-fluoro-N-(1-methylethyl)- → HCID 68510497, compound

HRID 1256918Notes

Reaction equation

HRID 1256918 reaction equation
[C:1]([CH2:3][CH2:4][CH:5]([C:13]([NH:15][S:16](/[CH:19]=[CH:20]/[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)(=[O:18])=[O:17])=[O:14])[C:6](N(CC)CC)=[O:7])#[N:2].[F:27][C:28]1[CH:37]=[CH:36][C:31]([NH:32][CH:33]([CH3:35])[CH3:34])=[CH:30][CH:29]=1>>[C:1]([CH2:3][CH2:4][CH:5]([C:13]([NH:15][S:16](/[CH:19]=[CH:20]/[C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)(=[O:17])=[O:18])=[O:14])[C:6]([N:32]([C:31]1[CH:36]=[CH:37][C:28]([F:27])=[CH:29][CH:30]=1)[CH:33]([CH3:35])[CH3:34])=[O:7])#[N:2]

Participants

3

Reactant 2

HCID 154403Benzenamine, 4-fluoro-N-(1-methylethyl)-HCID 86645225HCID 86645225, compound

Product 1

HCID 68510497HCID 68510497, compoundYield 41.9%

Procedure

In the same manner as in Example 1 (4), a crude product was obtained using the compound (657 mg) obtained in Example 216 (2) and 4-fluoro-N-isopropylaniline (306 mg). This was purified by silica gel column chromatography to give the title compound (334 mg) as a white powder.

Workup

  1. customThis was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-52781dc4c5e544868fbe5cbf29f28dcf
Source dataset
uspto-grants-2013_06
Patent number
US08461209B2

Reaction notes

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