Benzenamine, 4-fluoro-N-(1-methylethyl)- → N-(4-fluorophenyl)-N-isopropyl-2-(2-propynyl)-N'-((E)-styrylsulfonyl)malonamide

Participants

Reaction Steps

In the same manner as in Example 152 (3), the object compound was obtained using the compound (3.00 g) obtained in Example 152 (2) and trans-β-styrenesulfonamide (3.23 g). This was subjected to hydrolysis in the same manner as in Example 1 (3), and condensed with 4-fluoro-N-isopropylaniline (1.29 g) in the same manner as in Example 1 (4) to give a crude product. This was purified by silica gel column chromatography to give the title compound (1.25 g) as a white powder.

Provenance & Evidence