反应详情

A mixture of 250.2 g of metformin hydrochloride, 213.6 g of acetaldehyde diethyl acetal and 12.5 g of toluene-4-sulfonic acid monohydrate in 500 ml of isobutanol is heated under reflux for 40 hours. Some of the solvent is removed by distillation. The mixture is cooled to 10°, and the white precipitate is separated off, giving 224.7 g (77.4%) of 4-amino-3,6-dihydro-2-dimethylamino-6-methyl-1,3,5-triazine hydrochloride.

1. temperatureis heated
2. temperatureunder reflux for 40 hours
3. customSome of the solvent is removed by distillation
4. temperatureThe mixture is cooled to 10°
5. customthe white precipitate is separated off