Triethylamine → HCID 65479806, compound

Participants

Reaction Steps

To a solution of 2-(4-chlorophenyl)ethylamine (2.83 g) and triethylamine (1.46 ml) in tetrahydrofuran (50 ml), 4-(bromomethyl)benzenesulphonyl chloride (1.63 g) was added, and the mixed solution was stirred at room temperature for one hour. Ethyl acetate was added thereto, and the solution was washed with a saturated solution of ammonium chloride and then washed with water. The organic layer was dried over anhydrous magnesium sulfate, and evaporated under reduced pressure to remove the solvent. The resulting crude product was purified by column chromatography (neutral OH type silica gel, ethyl acetate/n-hexane=10 to 30%) to give 4-(bromomethyl)-N-[2-(4-chlorophenyl)ethyl]benzene sulfonamide (2.04 g) as a colorless solid.

Provenance & Evidence