3-Fluoro-4-methoxybenzoyl chloride → N-[1-Cyano-1-methyl-2-(4,6,7-trichloro-2H-indazol-2-yl)ethyl]-3-fluoro-4-methoxybenzamide

Participants

Reaction Steps

Using a procedure similar to that described in Example 60, except using a solution of 3-fluoro-4-methoxybenzoyl chloride (0.16 mmole) in THF and a solution of 2-amino-2-methyl-3-(4,6,7-trichloro-2H-indazol-2-yl)propionitrile (0.075 mmole, described in Example 147) in THF mixed with TEA (3% v./v.), the title compound was isolated as solid residue (6.6 mg). It was dissolved in DMSO for further biological evaluation and analyzed by LCMS. MS (ES): M/Z [M+H]=455, RT=0.69 min.

Provenance & Evidence