4-Phenoxybenzoyl chloride → N-[2-(6-Bromo-2H-pyrazolo[4,3-b]pyridin-2-yl)-1-cyano-1-methylethyl]-4-phenoxybenzamide

HRID 1257057노트

반응식

HRID 1257057 반응식
[O:1]([C:8]1[CH:16]=[CH:15][C:11]([C:12](Cl)=[O:13])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:17][C:18]([CH3:32])([CH2:21][N:22]1[CH:31]=[C:25]2[N:26]=[CH:27][C:28]([Br:30])=[CH:29][C:24]2=[N:23]1)[C:19]#[N:20]>C1COCC1>[Br:30][C:28]1[CH:27]=[N:26][C:25]2=[CH:31][N:22]([CH2:21][C:18]([NH:17][C:12](=[O:13])[C:11]3[CH:15]=[CH:16][C:8]([O:1][C:2]4[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=4)=[CH:9][CH:10]=3)([C:19]#[N:20])[CH3:32])[N:23]=[C:24]2[CH:29]=1

참가 물질

4

반응물 2

HCID 741934-Phenoxybenzoyl chlorideHCID 666201262-Amino-3-(6-bromo-2H-pyrazolo[4,3-b]pyridin-2-yl)-2-methylpropionitrile

생성물 1

HCID 68706734N-[2-(6-Bromo-2H-pyrazolo[4,3-b]pyridin-2-yl)-1-cyano-1-methylethyl]-4-phenoxybenzamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

Using a procedure similar to that described in Example 60, except using a solution of 4-phenoxybenzoyl chloride (0.16 mmole) in THF and a solution of 2-amino-3-(6-bromo-2H-pyrazolo[4,3-b]pyridin-2-yl)-2-methylpropionitrile (0.075 mmole, described in Example 182) in THF mixed with TEA (3% v./v.), the title compound was isolated as solid residue (6.7 mg). It was dissolved in DMSO for further biological evaluation and analyzed by LCMS. MS (ES): M/Z [M+H]=476, RT=0.63 min.

출처 및 근거

ORD 기록
ord-527d0470645347c5a20398fb166ee7c0
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08461176B2

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