4-(Trifluoromethyl)benzenecarbothioyl chloride → HCID 86641833, compound

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Reaction Steps

Using a procedure similar to that described in Example 1, except using 2-amino-3-(5,6-dibromo-2H-pyrazolo[4,3-b]pyridin-2-yl)-2-methylpropionitrile (60 mg, described in Example 195) and 4-trifluoromethylthiobenzoyl chloride (28 μL), the title compound was isolated as a white solid (44 mg, 47%). MS (ES): M/Z [M+H]=562. 1H NMR: (400 MHz, DMSO-d6): 1.68 (s, 3H), 5.13 (d, J=13.2 Hz, 1H), 5.18 (d, J=13.2 Hz, 1H), 7.88 (d, J=8.4 Hz, 2H), 7.94 (d, J=8.4 Hz, 2H), 8.74 (s, 1H), 8.79 (s, 1H) and 9.04 (s, 1H). 19F NMR (376 MHz, DMSO-d6): −41.9 (s, 3F).

Provenance & Evidence