4-(Trifluoromethyl)benzenecarbothioyl chloride → HCID 86641839, compound

Participants

Reaction Steps

Using a procedure similar to that described in Example 1, except using 2-amino-3-(7-bromo-2H-pyrazolo[3,4-c]pyridin-2-yl)-2-methylpropionitrile (100 mg, described in Example 202) and 4-trifluoromethylthiobenzoyl chloride (93 mg), the title compound was isolated as a white solid (153 mg, 89%). Rf=0.25 (1:1 EA/heptane). MS (ES): M/Z [M+H]=484. 1H NMR: (400 MHz, DMSO-d6): 1.70 (s, 3H), 5.18 (d, J=13.5 Hz, 1H), 5.33 (d, J=13.5 Hz, 1H), 7.76 (d, J=5.8 Hz, 1H), 7.87-7.90 (m, 3H), 7.96 (d, J=8.4 Hz, 1H), 8.71 (s 1H) and 9.01 (d, J=1.1 Hz, 1H). 19F NMR (376 MHz, DMSO-d6): −42.0 (s, 3F).

Provenance & Evidence