4-(Trifluoromethoxy)benzoyl Chloride → HCID 59327622, compound

Participants

Reaction Conditions

Reaction Steps

4-Trifluoromethoxybenzoyl chloride (14.5 mL) was added at around 0° C. to a cold solution of (R)-2-amino-3-(6-bromo-pyrazolo[4,3-b]pyridin-2-yl)-2-methyl-propionitrile (23.4 g, 95% ee) in dry THF (600 mL) mixed with TEA (13.4 mL). The reaction mixture was stirred for around 4 hours at around 0° C. The cold reaction mixture was then filtered through a short plug of Celite® and basic alumina and solvent evaporated under reduced pressure. The resulting residue was triturated with DCM to afford a solid that was isolated by filtration to give the title compound as a white solid (28.6 g, 73.1%, 99.6% analytical purity, 99% ee). The filtrate was collected and solvent evaporated under reduced pressure. The residue was loaded on silica gel and purified by chromatography (SiO2, heptane/EA) to afford a second crop of title compound as a white solid (4.1 g, 10.5%). MS (ES): M/Z [M+H]=468. 1H NMR: (400 MHz, CHLOROFORM-d): 1.94 (s, 3H), 4.86 (d, J=14.0 Hz, 1H), 5.02 (d, J=14.0 Hz, 1H), 7.33 (d, J=8.1 Hz, 2H), 7.83-7.92 (m, 2H), 8.02 (s, 1H), 8.21 (dd, J=2.0, 0.7 Hz, 1H), 8.40 (d, J=0.7 Hz, 1H) and 8.62 (d, J=2.0 Hz, 1H). 19F NMR (376 MHz, CHLOROFORM-d): −58.1 (s, 3F).

Provenance & Evidence