化工社化工社 化学情報印刷レポート · 研究参考用
Potassium Carbonate → 1-(2-Chloropyridin-4-ylmethyl)-4-acetylpiperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-Acetylpiperazine | HCID 83795 | — |
| 反応物 | 2-Chloro-4-(chloromethyl)pyridine | HCID 11126573 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-(2-Chloropyridin-4-ylmethyl)-4-acetylpiperazine | HCID 58285182 | — |
反応手順
N-Acetylpiperazine (1.0 equiv) was mixed with compound 2-chloro-4-(chloro-methyl)pyridine (1.0 equiv) and K2CO3 (4 equiv) in DMF. The mixture was stirred for 1 h at rt. After removing most of the solvent, the residue was partitioned in water and EtOAc. The organic layer was separated, dried over anhydrous Na2SO4, and evaporated in vacuo. The residue was purified by flash chromatography to give the title compound as a solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08461339B2 |
| 出典データセット | uspto-grants-2013_06 |
| ORD ID | ord-99434ad2b24e4ade9640c921364c5de3 |
| 出典メモ | uspto-grants-2013_06 |