Diethyl Oxalate → 3,4-Dihydroxy-thiophene-2,5-dicarboxylic acid diethyl ester

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Reaction Steps

The diethyl thioglycolate and diethyl oxalate are mixed, and then added to a first solution containing a first electron donor in the microwave reactor. The microwave reactor is heated by the 2.45 GHz microwave at a power of 100-500 W to perform a condensation reaction for 20-60 minutes to obtain 2,5-diethoxycarbonyl-3,4-dihydroxythiophene. The reaction is shown in the chemical formula (B).

Provenance & Evidence