反应详情

温度

0 °C

A 0° C. solution of N-(4-chloro-2-fluoro-3-formylphenyl)acetamide (1.1 g, 5.10 mmol) in MeOH (10 mL) was treated portion-wise with sodium borohydride (0.193 g, 5.10 mmol), stirred at 0° C. for 0.5 h, then warmed to RT and concentrated to dryness. The residue was treated with water, extracted with EtOAc (2×) and the combined organics were washed with brine, dried over Na2SO4 and concentrated to dryness to afford N-(4-chloro-2-fluoro-3-(hydroxymethyl)phenyl)acetamide (1.05 g, 95% yield) as a white solid. MS (ESI) m/z: 218.0 [M+H]+.

1. temperaturewarmed to RT
2. concentrationconcentrated to dryness
3. additionThe residue was treated with water
4. extractionextracted with EtOAc (2×)
5. washthe combined organics were washed with brine
6. dry with materialdried over Na2SO4
7. concentrationconcentrated to dryness