反应详情

温度

85 °C

2-(4-Fluoro-2-methyl-5-nitrophenyl)acetic acid (18.43 g, 86.5 mmol) and conc. H2SO4 (4.00 mL) were combined in EtOH (300 mL) and heated at 85° C. for 2.5 h. The mixture was cooled to RT, concentrated, the residue dissolved in MTBE and washed with H2O (2×), then brine (2×), dried (MgSO4), and evaporated to afford ethyl 2-(4-fluoro-2-methyl-5-nitrophenyl)acetate (16.79 g, 81% yield) as a dark orange oil which was used without further purification. MS (ESI) m/z: 242.0 (M+H)+.

1. temperatureThe mixture was cooled to RT
2. concentrationconcentrated
3. dissolutionthe residue dissolved in MTBE
4. washwashed with H2O (2×)
5. dry with materialbrine (2×), dried (MgSO4)
6. customevaporated