HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 86713633, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Carbamic acid, N-[3-[(4-methyl-1-piperazinyl)methyl]phenyl]-, 1,1-dimethylethyl ester | HCID 86713634 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 86713633 | HCID 86713633 | 90% |
Reaction Steps
A solution of tert-butyl (3-((4-methylpiperazin-1-yl)methyl)phenyl)carbamate (544 mg, 1.781 mmol) in dioxane (10 mL) was treated with HCl (g) for 10 min, then stirred at RT for 3 h. The mixture was concentrated to dryness to afford crude 3-((4-methylpiperazin-1-yl)methyl)aniline trihydrochloride (505 mg, 90% yield) which was used without further purification. MS (ESI) m/z: 306.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08461179B1 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-453adfb5aeb44f9eaa2d627853a1b2c1 |
| Source note | uspto-grants-2013_06 |