HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 12572Generated: October 25, 2026
Methanol → Methyl 4,5-Diphenyl-pyrimidine-2-carboxylate
https://huagongshe.com/reaction/12572
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | 2-Chloro-4,5-diphenylpyrimidine | HCID 12674276 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Catalyst | Ferrocene-1,1'-bis-(diphenylphosphine) | HCID 635956 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Methyl 4,5-Diphenyl-pyrimidine-2-carboxylate | HCID 59338828 | — |
Reaction Steps
A solution of 2-chloro-4,5-diphenyl-pyrimidine (107, 203 mg, 0.76 mmol) and sodium acetate (188 mg, 2.21 mmol) in MeOH (6 ml) and THF (2 ml) was degassed under argon for 10 min. Pd(OAc)2 (2.1 mg) and DPPF (13 mg) were added and CO (g) was bubbled through the solution. The reaction was heated to 110° C. in a sealed tube for 2 days. The solvent was removed in vacuo and the crude product was purified by column chromatography (10% ethyl acetate in hexane) to get the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07728014B2 |
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| Source dataset | uspto-grants-2010_06 |
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| ORD ID | ord-9bea9c85f39b4b5ab7219d457a1b1a99 |
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| Source note | uspto-grants-2010_06 |
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