2-Bromo-1-(3,4-dichlorophenyl)ethanone → HCID 58127540, compound

Participants

Reaction Steps

To a solution of ethyl 2-formyl-3-oxopropanoate (0.57 g, 3.0 mmol) in ethanol (5 mL) was added thiosemicarbazide (1.37 g, 15 mmol), and the reaction mixture was stirred at room temperature for 1 hr. 2-Bromo-1-(3,4-dichlorophenyl)ethanone (0.54 g, 2.0 mmol) was added, and the mixture was stirred at 80° C. for 30 min, and cooled to room temperature. The precipitated crystals were collected by filtration to give the title compound (545 mg, 74%) as orange crystals.

Provenance & Evidence