HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-3'-trifluoromethoxyacetophenone → ethyl 1-({4-[3-(trifluoromethoxy)phenyl]-1,3-thiazol-2-yl}methyl)-1H-pyrazole-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-3'-trifluoromethoxyacetophenone | HCID 2778687 | — |
| Reactant | Ethyl 1-(carbamothioylmethyl)-1H-pyrazole-4-carboxylate | HCID 58127901 | — |
| Product | ethyl 1-({4-[3-(trifluoromethoxy)phenyl]-1,3-thiazol-2-yl}methyl)-1H-pyrazole-4-carboxylate | HCID 66939647 | 86.3% |
Reaction Steps
By a reaction in the same manner as in Example 1c and using the compound (213 mg, 1.00 mmol) obtained in Example 1b and 2-bromo-1-[3-(trifluoromethoxy)phenyl]ethanone (283 mg, 1.00 mmol), the title compound (343 mg, 86%) was obtained as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08461348B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-864326ba83004944b3604d11e8baab9b |
| Source note | uspto-grants-2013_06 |