HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Trifluoromethyl)aniline → ethyl 1-[(4-{[3-(trifluoromethyl)phenyl]carbamoyl}-1,3-thiazol-2-yl)methyl]-1H-pyrazole-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Trifluoromethyl)aniline | HCID 7375 | — |
| Reactant | 2-{[4-(ethoxycarbonyl)-1H-pyrazol-1-yl]methyl}-1,3-thiazole-4-carboxylic acid | HCID 66939248 | — |
| Product | ethyl 1-[(4-{[3-(trifluoromethyl)phenyl]carbamoyl}-1,3-thiazol-2-yl)methyl]-1H-pyrazole-4-carboxylate | HCID 66938976 | 86.7% |
Reaction Steps
By a reaction in the same manner as in Reference Example 19 and using the compound (281 mg, 1.00 mmol) obtained in Example 4a and 3-(trifluoromethyl)aniline (0.149 mL, 1.20 mmol), the title compound (368 mg, 86%) was obtained as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08461348B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-12e4f5a4c41b4ce89f0ac7d5b5d2785e |
| Source note | uspto-grants-2013_06 |