2-Bromo-1-[3-(trifluoromethyl)phenyl]ethan-1-one → HCID 66939085, compound

HRID 1257315Notes

Reaction equation

HRID 1257315 reaction equation
[NH2:1][C:2](=[S:15])[CH2:3][N:4]1[C:8]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:7][C:6]([CH3:14])=[N:5]1.Br[CH2:17][C:18]([C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:29])([F:28])[F:27])[CH:21]=1)=O>>[CH3:14][C:6]1[CH:7]=[C:8]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[N:4]([CH2:3][C:2]2[S:15][CH:17]=[C:18]([C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:27])([F:28])[F:29])[CH:21]=3)[N:1]=2)[N:5]=1

Participants

3

Reactant 2

HCID 27783862-Bromo-1-[3-(trifluoromethyl)phenyl]ethan-1-oneHCID 86650586HCID 86650586, compound

Product 1

HCID 66939085HCID 66939085, compoundYield 94.6%

Procedure

By a reaction in the same manner as in Example 1c and using the compound (227 mg, 1.00 mmol) obtained in Example 7b and 2-bromo-1-[3-(trifluoromethyl)phenyl]ethanone (283 mg, 1.00 mmol), the title compound (374 mg, 94%) was obtained as a colorless oil.

Workup

  1. customBy a reaction in the same manner as in Example 1c

Sources & evidence

ORD record
ord-4535949b509246bcbd7ac813379397c3
Source dataset
uspto-grants-2013_06
Patent number
US08461348B2

Reaction notes

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