2-Bromo-1-[3-(trifluoromethyl)phenyl]ethan-1-one → HCID 66939476, compound

HRID 1257317Notes

Reaction equation

HRID 1257317 reaction equation
[NH2:1][C:2](=[S:17])[CH2:3][N:4]1[C:8]([O:9][CH2:10][CH3:11])=[C:7]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:6]=[N:5]1.Br[CH2:19][C:20]([C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([C:28]([F:31])([F:30])[F:29])[CH:23]=1)=O>>[CH2:10]([O:9][C:8]1[N:4]([CH2:3][C:2]2[S:17][CH:19]=[C:20]([C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([C:28]([F:29])([F:30])[F:31])[CH:23]=3)[N:1]=2)[N:5]=[CH:6][C:7]=1[C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH3:11]

Participants

3

Reactant 2

HCID 27783862-Bromo-1-[3-(trifluoromethyl)phenyl]ethan-1-oneHCID 86650588HCID 86650588, compound

Product 1

HCID 66939476HCID 66939476, compoundYield 83%

Procedure

By a reaction in the same manner as in Example 1c and using the compound (200 mg, 0.78 mmol) obtained in Example 8b and 2-bromo-1-[3-(trifluoromethyl)phenyl]ethanone (0.53 g, 2.0 mmol), the title compound (275 mg, 83%) was obtained as colorless crystals.

Workup

  1. customBy a reaction in the same manner as in Example 1c

Sources & evidence

ORD record
ord-8d3ac3455da4486cb39a26c79cf2858a
Source dataset
uspto-grants-2013_06
Patent number
US08461348B2

Reaction notes

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