HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-3'-trifluoromethoxyacetophenone → 5-methyl-1-({4-[3-(trifluoromethoxy)phenyl]-1,3-thiazol-2-yl}methyl)-1H-pyrazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-3'-trifluoromethoxyacetophenone | HCID 2778687 | — |
| Reactant | tert-butyl 1-(2-amino-2-thioxoethyl)-5-methyl-1H-pyrazole-4-carboxylate | HCID 58127752 | — |
| Product | 5-methyl-1-({4-[3-(trifluoromethoxy)phenyl]-1,3-thiazol-2-yl}methyl)-1H-pyrazole-4-carboxylic acid | HCID 66939341 | 74.6% |
Reaction Steps
A reaction similar to Example 1c was performed using the compound (200 mg, 0.783 mmol) obtained in Example 11b and 2-bromo-1-[3-(trifluoromethoxy)phenyl]ethanone (222 mg, 0.783 mmol). As a result, the title compound (224 mg, 74%) wherein tert-butyl ester was hydrolyzed by hydrobromic acid produced under the reaction conditions was obtained as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08461348B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-fc07d6b945d24ffbb9982171bf392d05 |
| Source note | uspto-grants-2013_06 |