ethyl 1H-pyrazole-4-carboxylate → HCID 66939138, compound

HRID 1257322Notes

Reaction equation

HRID 1257322 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH:3]=[N:2]1.Br[CH:12]([CH3:20])[C:13]([O:15]C(C)(C)C)=[O:14]>>[CH2:9]([O:8][C:6]([C:4]1[CH:5]=[N:1][N:2]([CH:12]([CH3:20])[C:13]([OH:15])=[O:14])[CH:3]=1)=[O:7])[CH3:10]

Participants

3

Reactant 2

HCID 142179ethyl 1H-pyrazole-4-carboxylateHCID 545327tert-Butyl 2-bromopropanoate

Product 1

HCID 66939138HCID 66939138, compoundYield 87.2%

Procedure

By a reaction in the same manner as in Example 10a and using ethyl 1H-pyrazole-4-carboxylate (1.40 g, 10.0 mmol) and tert-butyl 2-bromopropanate (3.14 g, 15.0 mmol), the title compound (1.85 g, 87%) was obtained as a colorless oil.

Workup

  1. customBy a reaction in the same manner as in Example 10a

Sources & evidence

ORD record
ord-cf253859d55c4bff952a73af0a9ddc88
Source dataset
uspto-grants-2013_06
Patent number
US08461348B2

Reaction notes

Loading…