tert-Butyl 2-bromo-2-methylpropionate → HCID 66939689, compound

HRID 1257325Notes

Reaction equation

HRID 1257325 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH:3]=[N:2]1.Br[C:12]([CH3:21])([CH3:20])[C:13]([O:15]C(C)(C)C)=[O:14]>>[CH2:9]([O:8][C:6]([C:4]1[CH:5]=[N:1][N:2]([C:12]([CH3:21])([CH3:20])[C:13]([OH:15])=[O:14])[CH:3]=1)=[O:7])[CH3:10]

Participants

3

Reactant 2

HCID 90290tert-Butyl 2-bromo-2-methylpropionateHCID 142179ethyl 1H-pyrazole-4-carboxylate

Product 1

HCID 66939689HCID 66939689, compoundYield 83.1%

Procedure

By a reaction in the same manner as in Example 10a and using ethyl 1H-pyrazole-4-carboxylate (1.40 g, 10.0 mmol) and tert-butyl 2-bromo-2-methylpropanate (6.70 g, 30.0 mmol), the title compound (1.88 g, 83%) was obtained as a colorless oil.

Workup

  1. customBy a reaction in the same manner as in Example 10a

Sources & evidence

ORD record
ord-38ef0c32aa4642b6993a705bd44c7ef5
Source dataset
uspto-grants-2013_06
Patent number
US08461348B2

Reaction notes

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