2-Bromo-1-[3-(trifluoromethyl)phenyl]ethan-1-one → HCID 66939656, compound

HRID 1257326Notes

Reaction equation

HRID 1257326 reaction equation
[NH2:1][C:2](=[S:16])[C:3]([N:6]1[CH:10]=[C:9]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:8]=[N:7]1)([CH3:5])[CH3:4].Br[CH2:18][C:19]([C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([C:27]([F:30])([F:29])[F:28])[CH:22]=1)=O>>[CH3:4][C:3]([N:6]1[CH:10]=[C:9]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:8]=[N:7]1)([C:2]1[S:16][CH:18]=[C:19]([C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([C:27]([F:28])([F:29])[F:30])[CH:22]=2)[N:1]=1)[CH3:5]

Participants

3

Reactant 2

HCID 27783862-Bromo-1-[3-(trifluoromethyl)phenyl]ethan-1-oneHCID 58127897HCID 58127897, compound

Product 1

HCID 66939656HCID 66939656, compoundYield 91.3%

Procedure

By a reaction in the same manner as in Example 1c and using the compound (241 mg, 1.00 mmol) obtained in Example 16b and 2-bromo-1-[3-(trifluoromethyl)phenyl]ethanone (267 mg, 1.00 mmol), the title compound (374 mg, 91%) was obtained as a colorless oil.

Workup

  1. customBy a reaction in the same manner as in Example 1c

Sources & evidence

ORD record
ord-e0088257a40c481787183cb4a669b3a1
Source dataset
uspto-grants-2013_06
Patent number
US08461348B2

Reaction notes

Loading…