2-Bromo-1-(3-nitrophenyl)ethan-1-one → HCID 58127481, 화합물

HRID 1257333노트

반응식

HRID 1257333 반응식
[NH2:1][C:2](=[S:14])[CH2:3][N:4]1[CH:8]=[C:7]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:6]=[N:5]1.Br[CH2:16][C:17]([C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([N+:25]([O-:27])=[O:26])[CH:20]=1)=O>C(O)C>[N+:25]([C:21]1[CH:20]=[C:19]([C:17]2[N:1]=[C:2]([CH2:3][N:4]3[CH:8]=[C:7]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:6]=[N:5]3)[S:14][CH:16]=2)[CH:24]=[CH:23][CH:22]=1)([O-:27])=[O:26]

참가 물질

4

반응물 2

HCID 752132-Bromo-1-(3-nitrophenyl)ethan-1-oneHCID 58127901Ethyl 1-(carbamothioylmethyl)-1H-pyrazole-4-carboxylate

생성물 1

HCID 58127481HCID 58127481, 화합물수율 93%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution (24 mL) of the compound (2.2 g, 10.2 mmol) obtained in Example 1b and 2-bromo-1-(3-nitrophenyl)ethanone (3.0 g, 12.3 mmol) in ethanol was heated under reflux overnight, and the mixture was cooled to room temperature. The solvent was evaporated under reduced pressure, and the produced crude title compound was recrystallized (ethyl acetate-hexane) to give the title compound (3.4 g, 78%) as colorless crystals.

후처리

  1. temperatureunder reflux overnight
  2. customThe solvent was evaporated under reduced pressure
  3. customthe produced crude title compound
  4. customwas recrystallized (ethyl acetate-hexane)

출처 및 근거

ORD 기록
ord-140c5566f0f24e959a0f4b3dc9af8e31
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08461348B2

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