Hydrochloric Acid → 1-({5-methyl-4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)-1H-pyrazole-4-carboxylic acid

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To a solution (3 mL) of the compound (112 mg, 0.28 mmol) obtained in Example 34a in ethanol was added 2N aqueous sodium hydroxide solution (0.56 mL, 1.08 mmol), and the mixture was stirred at room temperature for 5 hr. The reaction mixture was neutralized with 1N aqueous hydrochloric acid solution, saturated brine was added, and the mixture was extracted with ethyl acetate. The obtained organic layer was washed with saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure. The obtained crude product was purified by recrystallization (ethyl acetate-hexane) to give the title compound (49 mg, 48%) as colorless crystals.

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