HCID 58127583, compound → HCID 58127606, compound

HRID 1257351Notes

Reaction equation

HRID 1257351 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12]([CH2:15][N:16]3[CH:20]=[C:19]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[CH:18]=[N:17]3)[S:13][CH:14]=2)=[CH:6][CH:5]=1)([O-])=O>C(O)C.O1CCCC1.[C].[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12]([CH2:15][N:16]3[CH:20]=[C:19]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[CH:18]=[N:17]3)[S:13][CH:14]=2)=[CH:6][CH:5]=1

Participants

4

Reactant 1

HCID 58127583HCID 58127583, compound

Product 1

HCID 58127606HCID 58127606, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 21873804Tetrahydrofuran ethanolSolvent

Procedure

To a mixed solution of the compound (1.5 g, 4.2 mmol) obtained in Example 36a in ethanol/tetrahydrofuran (v/v=1/1, 20 mL) was added palladium-carbon (10% wet., 150 mg), and the mixture was stirred at room temperature for 3 hr under a hydrogen atmosphere (1 atm). Palladium-carbon was removed by filtration and the solvent was evaporated under reduced pressure to give a crude title compound.

Workup

  1. customPalladium-carbon was removed by filtration
  2. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-d7852c64becc449fa21c70913505b6ca
Source dataset
uspto-grants-2013_06
Patent number
US08461348B2

Reaction notes

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