Water → HCID 66939508, compound

Participants

Reaction Steps

To a mixed solution of the compound (260 mg, 0.65 mmol) obtained in Example 39c in ethanol/tetrahydrofuran (v/v=1/1, 6 mL) was added 2N aqueous sodium hydroxide solution (1.3 mL, 2.6 mmol), and the mixture was stirred at room temperature overnight. Water was added to the reaction mixture and the aqueous layer was washed with diethyl ether, neutralized with 1N aqueous hydrochloric acid solution, and the mixture was extracted with ethyl acetate. The obtained organic layer was washed with saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure. The resulting crude title compound was recrystallized (ethyl acetate-hexane) to give the title compound (160 mg, 69%) as colorless crystals.

Provenance & Evidence