Hydrochloric Acid → HCID 56706473, compound

Participants

Reaction Conditions

Reaction Steps

Under a nitrogen atmosphere at 0° C., to a solution (4 mL) of the compound (7.4 g, 25 mmol) obtained in Example 64a in tetrahydrofuran was added lithium tetrahydroborate (2.6 g, 49 mmol), and the mixture was stirred at 80° C. for 5 hr. 1N Hydrochloric acid was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The obtained organic layer was washed with saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure. The resulting crude title compound was purified by column chromatography (hexane-hexane/ethyl acetate=50/50) to give the title compound (5.4 g, 85%) as a colorless solid.

Provenance & Evidence