Hydrochloric Acid → HCID 66939684, compound

Participants

Reaction Steps

Under a nitrogen atmosphere at 0° C., to a solution (5 mL) of the compound (310 mg, 1.1 mmol) obtained in Example 71a in tetrahydrofuran was added borane-tetrahydrofuran complex (1.1 M tetrahydrofuran solution, 3.0 mL, 3.3 mmol), and the mixture was stirred at room temperature overnight. 1N Hydrochloric acid was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The obtained organic layer was washed with saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure. The resulting crude title compound was purified by column chromatography (hexane-hexane/ethyl acetate=65/35) to give the title compound (82 mg, 27%) as a colorless oil.

Provenance & Evidence