Triethylamine → HCID 58127830, compound

Participants

Reaction Steps

To a solution (16 mL) of the compound (3.0 g, 16 mmol) obtained in Example 72a in N,N-dimethylformamide were added 3-trifluoromethylbenzoic acid (3.2 g, 17 mmol), N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide (3.6 g, 19 mmol), 1-hydroxybenzotriazole (2.9 g, 19 mmol) and triethylamine (4.3 mL, 31 mmol), and the mixture was stirred at room temperature overnight. Saturated aqueous sodium hydrogen carbonate solution was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The obtained organic layer was washed with saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure. The resulting crude title compound was purified by column chromatography (hexane-hexane/ethyl acetate=70/30) to give the title compound (4.0 g, 66%) as a colorless oil.

Provenance & Evidence