Pyridine → ethyl 1-[(4-{3-[(Z)-2-pyridin-3-ylethenyl]-5-(trifluoromethyl)phenyl}-1,3-thiazol-2-yl)methyl]-1H-pyrazole-4-carboxylate

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Reaction Steps

To a solution (10 mL) of the compound (980 mg, 2.0 mmol) obtained in Example 87a in ethanol were added pyridine (480 mg, 6.1 mmol) and palladium-barium sulfate (490 mg), and the mixture was stirred at room temperature for 5 hr under a hydrogen atmosphere (1 atm). Palladium-carbon was removed and the solvent was evaporated under reduced pressure. The resulting crude title compound was purified by column chromatography (hexane-hexane/ethyl acetate=35/65) to give the title compound (450 mg, 46%) as colorless crystals.

Provenance & Evidence