Sodium Bicarbonate → HCID 66939419, compound

Participants

Reaction Conditions

Reaction Steps

To a solution (10 mL) of the compound (350 mg, 0.93 mmol) obtained in Example 89d in methanol was added p-toluenesulfonic acid monohydrate (530 mg, 2.8 mmol), and the mixture was stirred at 70° C. for 4 hr. The reaction mixture was neutralized with saturated aqueous sodium hydrogen carbonate, and the mixture was extracted with ethyl acetate. The obtained organic layer was washed with saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure. The resulting crude title compound was purified by column chromatography (hexane-hexane/ethyl acetate=75/25) to give the title compound (150 mg, 56%) as a colorless oil.

Provenance & Evidence