Lithium Hydroxide → HCID 58127833, compound

Participants

Reaction Steps

To a solution of the compound (660 mg) obtained in Example 106a in tetrahydrofuran (5 ml) was added 2N lithium hydroxide aqueous solution (5 mL), and the mixture was heated under reflux overnight. The reaction mixture was concentrated under reduced pressure, and the residue was diluted with water, and adjusted to pH 5-6 with 3N hydrochloric acid. The resulting precipitate was collected by filtration. The obtained solid was dissolved in tetrahydrofuran and dried over anhydrous sodium sulfate, and the solvent was evaporated. The residue was recrystallized from ethanol to give the title compound (150 mg) as colorless crystals.

Provenance & Evidence