Triphenylphosphine → HCID 66939147, compound

Participants

Reaction Steps

A solution of the compound (0.40 g) obtained in Example 127b, ethyl 1H-pyrazole-4-carboxylate (0.26 g) and triphenylphosphine (0.49 g) in tetrahydrofuran (8 mL) was cooled in an ice bath, diethyl azodicarboxylate (0.30 mL) was added, and the mixture was stirred at the same temperature for 1 hr. Saturated aqueous ammonium chloride solution was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The obtained organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure and the residue was purified by column chromatography (carrier: silica gel, eluent: hexane/ethyl acetate) to give the title compound (0.35 g) as a solid.

Provenance & Evidence