Hydrochloric Acid → HCID 66939110, compound

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Reaction Steps

The compound (0.35 g) obtained in Example 127c was dissolved in ethanol (3 mL), and 6N aqueous sodium hydroxide solution (0.77 mL) was added. The reaction mixture was heated under reflux for 2 hr, cooled in an ice bath, adjusted to pH 2 with 6N hydrochloric acid, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was dried over magnesium sulfate, concentrated under reduced pressure, and the residue was purified by column chromatography (carrier: silica gel, eluent: dichloromethane/methanol) to give the title compound (0.25 g) as a colorless solid.

Provenance & Evidence