HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Cesium carbonate → Methyl 5-methyl-4-[3-(trifluoromethyl)phenyl]furan-2-carboxylate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Cesium carbonate | HCID 10796 | — |
| Edukt | Methyl 4-bromo-5-methylfuran-2-carboxylate | HCID 604544 | — |
| Edukt | 3-(Trifluoromethyl)phenylboronic acid | HCID 2734388 | — |
| Katalysator | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Produkt | Methyl 5-methyl-4-[3-(trifluoromethyl)phenyl]furan-2-carboxylate | HCID 66939668 | 61,6% |
Reaktionsschritte
By a method similar to that in Example 126c and using the compound (1.00 g) obtained in Example 128b, 3-(trifluoromethyl)phenylboronic acid (1.04 g), cesium carbonate (2.98 g, 3.6 mmol), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (0.19 g), the title compound (0.80 g) was obtained as a solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08461348B2 |
| Quelldatensatz | uspto-grants-2013_06 |
| ORD ID | ord-1f74dbfc745b413db299c206ace20811 |
| Quellennotiz | uspto-grants-2013_06 |