HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-(cyanomethyl)benzoate → Ethyl 3-(2-amino-2-thioxoethyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-(cyanomethyl)benzoate | HCID 83311 | — |
| Reactant | Diethyl dithiophosphate, potassium salt | HCID 1385274 | — |
| Reactant | Hydrogen chloride-ethyl acetate | HCID 21866389 | — |
| Product | Ethyl 3-(2-amino-2-thioxoethyl)benzoate | HCID 58127520 | 79% |
Reaction Steps
By a method similar to that in Example 178a and using the compound (4.23 g, 22.4 mmol) obtained in Example 180a, 4M hydrogen chloride-ethyl acetate solution (42 mL) and O,O-diethyl dithiophosphate (4.50 mL, 26.8 mmol), the title compound (3.94 g, 79%) was obtained as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08461348B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-4666f35883284338bbe37402d3b8c5ea |
| Source note | uspto-grants-2013_06 |