HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-1-[3-(trifluoromethyl)phenyl]ethan-1-one → Methyl 3-({4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-1-[3-(trifluoromethyl)phenyl]ethan-1-one | HCID 2778386 | — |
| Reactant | Ethyl 3-(2-amino-2-thioxoethyl)benzoate | HCID 58127520 | — |
| Product | Methyl 3-({4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)benzoate | HCID 66939129 | 99.9% |
Reaction Steps
By a reaction in the same manner as in Example 178b and using the compound (223 mg, 1.00 mmol) obtained in Example 180b and 2-bromo-1-[3-(trifluoromethyl)phenyl]ethanone (267 mg, 1.0 mmol), the title compound (377 mg, 96%) was obtained as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08461348B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-4ea90ebad6d5483b9a115c3bd4300420 |
| Source note | uspto-grants-2013_06 |