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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1257452Generated: November 2, 2026

2-Bromo-1-[3-(trifluoromethyl)phenyl]ethan-1-one → Methyl 4-[3-(3-bromophenyl)-1-{4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}propyl]benzoate

https://huagongshe.com/reaction/1257452

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Bromo-1-[3-(trifluoromethyl)phenyl]ethan-1-oneHCID 2778386—
ReactantMethyl 4-[3-(3-bromophenyl)-1-carbamothioylpropyl]benzoateHCID 58127970—
ProductMethyl 4-[3-(3-bromophenyl)-1-{4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}propyl]benzoateHCID 6693941090%

Reaction Steps

By a reaction in the same manner as in Example 178b and using the compound (3.15 g, 8.03 mmol) obtained in Example 181b and 2-bromo-1-[3-(trifluoromethyl)phenyl]ethanone (3.22 g, 12.0 mmol), the title compound (4.03 g, 90%) was obtained as a yellow oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08461348B2
Source datasetuspto-grants-2013_06
ORD IDord-29e3b14b16b84377ad7b5e4b03ac1a3c
Source noteuspto-grants-2013_06