HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-1-[3-(trifluoromethyl)phenyl]ethan-1-one → Methyl 4-[3-(3-bromophenyl)-1-{4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}propyl]benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-1-[3-(trifluoromethyl)phenyl]ethan-1-one | HCID 2778386 | — |
| Reactant | Methyl 4-[3-(3-bromophenyl)-1-carbamothioylpropyl]benzoate | HCID 58127970 | — |
| Product | Methyl 4-[3-(3-bromophenyl)-1-{4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}propyl]benzoate | HCID 66939410 | 90% |
Reaction Steps
By a reaction in the same manner as in Example 178b and using the compound (3.15 g, 8.03 mmol) obtained in Example 181b and 2-bromo-1-[3-(trifluoromethyl)phenyl]ethanone (3.22 g, 12.0 mmol), the title compound (4.03 g, 90%) was obtained as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08461348B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-29e3b14b16b84377ad7b5e4b03ac1a3c |
| Source note | uspto-grants-2013_06 |