Ethyl thiooxamate → Ethyl 4-[3-(trifluoromethyl)phenyl]-1,3-thiazole-2-carboxylate

Participants

Reaction Conditions

Reaction Steps

To 2-bromo-1-[3-(trifluoromethyl)phenyl]ethanone (14 g, 41 mmol) was added ethyl amino(thioxo)acetate (5.0 g, 38 mmol), and the mixture was stirred at 80° C. for 3 hr. The solvent was evaporated under reduced pressure, and the obtained crude product was purified by recrystallization (ethyl acetate) to give the title compound (5.6 g, 49%) as colorless crystals.

Provenance & Evidence