Hydrochloric Acid → HCID 66939544, compound

Participants

Reaction Steps

A mixture of the compound (0.65 g) obtained in Example 198b, 2N aqueous sodium hydroxide solution (10 mL) and ethanol (10 mL) was stirred at room temperature for 4 hr. To the reaction mixture was added 1N hydrochloric acid, and the mixture was adjusted to pH 2-3 and extracted with ethyl acetate. The ethyl acetate layer was washed with saturated brine, dried over sodium sulfate, and concentrated under reduced pressure. The residue was purified by preparative liquid chromatography to give the title compound (0.21 g) as a colorless solid.

Provenance & Evidence